Gentamicin (as the sulphate) 100,000 i.u./mL in a clear solution for injection.
Gentamicin is an extremely stable and active antibiotic. The sulphate solution is slightly acid; however, gentamicin is more active in an alkaline medium (as may occur physiologically). Gentamicin, as an aminoglycoside, interferes with ribosomal peptide protein synthesis at both the RNA and ribosomal cycle stages producing a bactericidal action. It is active against a wide range of Gram-ve and Gram+ve bacteria isolated from domestic animals, eg. Klebsiella spp, Pseudomonas spp, Proteus spp, E. coli, Salmonella spp, Mycoplasma spp, Aerobacter spp, Staphylococcus(both penicillinase negative and positive) spp, and Streptococcusspp. Excretion is mainly through the kidneys, and a small amount through the bile. The recommended intramuscular dose produces a serum concentration that is bactericidal for most bacteria within an hour, and these concentrations last for 6-12 hours. Development of resistance to gentamicin is slow.
Treatment and control of infections caused by gentamicin sensitive organisms in horses, dogs and cats.
Do not use concurrently with general anaesthetics, muscle relaxants or high potency diuretics. Do not use in pregnant animals or those with impaired kidney function. In rare cases hypersensitivity can occur, in which case discontinue and institute appropriate therapy. Irritation at the injection site has been reported in dogs and cats. Avoid extended or excessive dosage, and concomitant use with other ototoxic products, as nephrotoxic and ototoxic effects may occur.
For infections, administer by i/m injection. Where dosage is i/m in food producing animals, give the injection into the anterior half of the neck. Administer at a dosage of 2mg/kg b.w. tid. ie. 2mL/100kg three times per day.
For intrauterine treatment, give 1.0-2.5g (10-25mL) daily for 3-5 days during oestrus while the cervix is relaxed, allowing easy penetration with a catheter. Dilute with 250-500mL of normal saline just prior to use. Although gentamicin is not spermicidal, avoid treatment on the day of breeding.
DOGS and CATS: For infections, administer by i/m or s/c injection at a dosage of 5mg/kg b.w. bid initially, ie. 0.5mL/10kg two times on day 1; then once a day for 3-5 days depending on response. If no response, or a poor response is seen after 7 days, investigate antibiotic sensitivity of the infective organism. Alkalinisation of the urine improves the activity of gentamicin in urinary tract infections.
MEAT: Horses producing meat or offal for human consumption must not be sold for slaughter either during treatment or within 63 days of the last treatment.
Safety Data Sheet available upon request
- Gentamicin (as the sulphate) 100,000 i.u./mL in a clear solution for injection.
- Available in 100mL clear, amber glass vials.
Product code: 9640
Restricted Veterinary Medicine: A010555